SIRT1 and Hyperglycemia: Downregulation of SIRT1 in hyperglycemic thrombi is associated with an increase in the level of the proinflammatory transcription factor NF-κB, suggesting that oxidative stress-induced miR33/SIRT1 pathways could play a key role in the proinflammatory/procoagulative state and thrombus burden caused by hyperglycemia [13].