Dominant TF motifs enriched in C2 were AP-1 complex motifs of the JUN, FOS, ATF, and MAF families and motifs of the MAF dimerizing proteins NRF2, BACH1, and BACH2, which have also been associated with cancer progression and metastasis38 and are plausible candidates to regulate the mesenchymal features of C2 cultures. Here, JUN is linked to cancer.