PDGFRA and glioblastoma: The fact that one oncogenic driver (PDGFRA activation) could reproduce the epigenetic heterogeneity of human GBM was in line with results from the comprehensive single cell RNA-seq analysis of human GBM7 where multiple cellular states were shown to be present in all investigated tumors, while state distributions were proposed to be dictated by certain genetic factors such as PDGFRA.