In contrast, HHV-8 was associated with both aggressive (OR 2.62; 95% CI: 1.36–5.06) and non-aggressive prostate cancer (OR 2.06; 95% CI: 1.25–3.38) among men carrying at least one ΔG allele (Table 5), again indicating that HHV-8 is a prostate cancer risk factor if men harbor the IFNL4-ΔG germline variant—independent of race/ethnicity. This evidence concerns the gene IFNL4 and prostate cancer.