Although RBD is the immunodominant region eliciting SARS-CoV-2-neutralizing antibodies40,41, and that the vast majority (~90%) of neutralizing antibodies detected after a natural human infection bind to RBD11, only the full S vaccine, but not other constructs expressing the S1 protein subunit or any of the two versions of RBD, was able to induce strong immune responses that protected animals against the infection. The gene discussed is PSMD1; the disease is infection.