Our data showed that 14-days treatment of diabetes mice with compound 3 (50 mg/kg, po) significantly increased Bdnf gene expression in the hippocampus of mice compared to untreated group (95% CI [0.9662, 1.496], *p < 0.05, F = 1.484; Fig. 8A), whereas other compounds did not significantly affect the expression level of the studied gene (p > 0.05). The gene discussed is BDNF; the disease is diabetes mellitus.