There was a significant positive, very high linear correlation between the level of interleukin 6 (r = 0.788, *p < 0.05), TNFα (r = 0.817, *p < 0.05) in prefrontal cortex and cognitive impairment in diabetics mice in Y Maze Novelty Preference Test (NPT). The gene discussed is TNF; the disease is Cognitive impairment.