Notably, we find that lack of AP-2β leads to β-catenin hyperactivation and increased 4E-BP1 and p70 S6 kinase phosphorylation in the distal nephron that is associated with renal cyst formation, renal fibrosis, and histopathologic features that partly overlap with those observed in mice that overexpress TFEB in the renal tubular epithelium (multilayered epithelial cells, clear cells, micropapillae)44. Here, TFEB is linked to cystic kidney disease.