TFAP2B and glomerulosclerosis: The occurrence of glomerulosclerosis in aged Six2Cre+Tfap2bfl/WT mice but not in 1-2 months-old Six2Cre+Tfap2bfl/fl mice, and the observation that glomeruli do not express AP-2β, suggests that the progressive glomerulosclerosis in Six2Cre+Tfap2bfl/WT mice occurs as a secondary consequence of the chronic tubular and tubulointerstitial abnormalities in the kidneys of these mice.