Furthermore, we found that viral infection had no marked effects on transcription of CYP11A1 and HSD3B2 genes (Fig. 1d) as well as P4 production (Fig. 1e) in cultured chorionic epithelial cell line JEG-3, which naturally produces P4.52 In these experiments, viral infection induced transcription of IFNB1 gene in these cells (Fig. 1d), suggesting that the cells are successfully infected. This evidence concerns the gene HSD3B2 and viral infectious disease.