Our analyses found an association between the presence of the BRAF V600E mutation and the unicystic histotype, in agreement with the literature (72%–100%).9,17,21,26,36,40,42 A heterogeneous mutational trend emerged in conventional ameloblastoma, depending on the detection methods used.9,17,21,24,26,27,30,36–42 The BRAF V600E mutation was only detected in mandibular ameloblastomas; this association has been demonstrated by others, reporting a high prevalence (82%–100%) of the mandibular localization.21,24,26,36,40. This evidence concerns the gene BRAF and ameloblastoma.