Thus, BRAF V600E ameloblastomas with multiple mutations could acquire several characteristics from the additional mutated genes.44 Finally, “Kondo et al.” showed gene and protein expression levels related to KRAS-responsive, EGFR-induced and TGF-B-related genes, tenfold higher in mandibular ameloblastomas, compared to corresponding healthy mucosa samples.30 The gene discussed is BRAF; the disease is ameloblastoma.