PIK3CA and ameloblastoma: In literature, RAS mutations occurred in 20%–53% of BRAF wild-type cases (KRAS: 8%–15%; NRAS: 6%–14%; HRAS: 6%) and some Authors suggest the hypothesis of a mutual exclusivity with BRAF mutation.10,16,19,20,26,30,52 Also, PI3K gene mutation has been highly detected in ameloblastomas (66.7%–100%),53–55 and its level seems to be correlated to plexiform pattern.55