From the results obtained in the present study, we came to a conclusion that JMJD2C induced upregulation of MDM2 by removing the H3K9me3 modification of MDM2 promoter, thereby promoting the ubiquitination of p53 and thus increasing the expression of IL5RA, which increases CDDP resistance in uveal melanoma (Fig. 7). This evidence concerns the gene TP53 and uveal melanoma.