For further exploration of the effect of MDM2-mediated p53/IL5RA on the drug resistance in uveal melanoma cells, we treated the MUM-2B cells with oe-MDM2 + oe-NC or oe-MDM2 + oe-p53 and MUM-2B/CDDP cells with oe-p53 + oe-NC or oe-p53 + oe-IL5RA in combination. The gene discussed is MDM2; the disease is uveal melanoma.