Further, we tested SHANK1, SHANK2, and SHANK3 protein expression in multiple NSCLC cell lines (A549, H1299, H1650, H292, SK-MES-1) compared with BEAS-2B cells (epithelial cells isolated from normal human bronchial epithelium from autopsy of non-cancerous individuals), and found SHANK1 expression was elevated in most NSCLC cell lines (Fig. 1F, G). Here, SHANK3 is linked to non-small cell lung carcinoma.