As an example, ß-Catenin was show to cooperate with MLL-AF9 in order to develop into aggressive leukemia, while ß-Catenin k.o. mice were quite restricted to develop leukemia in the presence of MLL-AF9, and finally, a pharmacological depletion of ß-Catenin by Indomethacin had the similar effect of preventing leukemia development [30]. This evidence concerns the gene KMT2A and leukemia.