This effects might be even super-enhanced by FRAT1 and FRAT1 which are overexpressed target genes in in MLL-r leukemias and allow to disable GSK3ß, which in turn increase again the steady-state ß-Catenin protein levels and cause subsequntly an increased self-renewal and proliferation capacity [32]. The gene discussed is KMT2A; the disease is leukemia.