After constructing the model, the risk score of each DLBCL patient in the training cohort was computed based on the following formula: risk score = NR3C1 × (− 0.285969433071478) + IGFBP3 × (− 0.16695536054869) + RARRES2 × (− 0.14291303044122) + F5 × (− 0.0961037965837689) + APOC1 × (− 0.0768487272489624) + CSF2RA × (− 0.056110125649913) + ENPP1 × (− 0.0221430402174049) + GYG1 × 0.0449620982512186 + PHKA1 × 0.0693510636252306 + CPT1A × 0.0752116074259248 + PDK4 × 0.0767229743647787 + CLOCK × 0.0858851468938173 + CTH × 0.108708800807851 + PLTP × 0.16013617077787. The gene discussed is CLOCK; the disease is diffuse large B-cell lymphoma.