Hdac2 and Pik3r2 can promote biological processes of chronic myeloid leukemia, longevity regulating pathway-multiple species, thyroid hormone signaling pathway, microRNAs in cancer, epstein-barr virus infection and viral carcinogenesis and human papillomavirus infection.The expression of Rbx1 and Pik3r2 promoted the processes of renal cell carcinoma, HIF-1 signaling pathway, and human immunodeficiency virus 1 infection. The gene discussed is RBX1; the disease is hereditary clear cell renal cell carcinoma.