In neonatal mice, stabilizing HIF-1α (the master regulator of VEGF) with dimethyloxalylglycine (DMOG) resulted in decreased incidence of severe NEC, increased intestinal VEGF expression, and increased villus endothelial and epithelial proliferation, these effects are VEGFR2-dependent [61]. This evidence concerns the gene VEGFA and necrotizing enterocolitis.