Furthermore, LINC00022 overexpression significantly decreased the expression of miR-375-3p (0.5 fold vs Lv-NC group) and increased FOXF1 (5.4 fold vs Lv-NC group) mRNA level in CRC cells, whereas LINC00022 knockdown had the opposite effect (miR-375-3p, 3.0–4.0 fold; FOXF1, 0.4–0.5 fold vs Lv-anti-NC group, Fig. 6b). This evidence concerns the gene FOXF1 and colorectal carcinoma.