We identified HLA-DRB1 amino acid positions 4, 57, 60 and 78 associated OBI, which have been associated with autoimmune disease: position 57 with Vogt-Kusanagi-Harada’s disease [44], positions 60 with multiple sclerosis [45, 46], position 78 with primary biliary cirrhosis [47], indicating the auto immunogenic potential of these HLA-DRB1 amino acid positions susceptible to OBI. This evidence concerns the gene HLA-DRB1 and primary biliary cholangitis.