The histological grade (HG) of the invasive carcinomas is an important feature and must be evaluated to guide the therapeutic approach and predict the prognosis.28In the increased risk group, the frequency of HG3 was higher (p < 0.01), as well as Ki-67 ≥ 25% (p < 0.01), compared with the usual risk group. Here, MKI67 is linked to invasive carcinoma.