ESR1 and breast cancer: Regarding hormone receptors (HR), the higher frequency of cases with absence HR was observed in the increased risk for hereditary breast cancer group, compared with the usual risk group (p < 0.01), which reinforces the premise that women at risk for hereditary predisposition are more prone to estrogen receptor negativity.30The presence of hormone receptors in tumor tissue is related to indicators of good prognosis, with a lower histological grade and lower rates of cell proliferation.3, 4, 18