To extend and confirm our findings in human CRC cells, we generated mice harbouring common CRC mutations, Apc and Kras, targeted to the intestinal epithelium (VilCreER;Apcfl/fl;KrasG12D/+, hereafter AK) and crossed them to Bcl3-/- mice (VilCreER;Apcfl/fl;KrasG12D/+;Bcl3-/-, hereafter AKBKO). This evidence concerns the gene KRAS and colorectal carcinoma.