To further validate fibroblast differentiation in PIC-RGD gels,we analyzed the expression of some genes related to fibrosis: αSMA, Col1α1, p53, and Ki67, where αSMA and Col1α1 encode for αSMA and type I collagen,respectively, p53 encodes for the transcription factorp53, which is strongly involved in wound healing30 (and cancer), and Ki67 encodes for theproliferation marker Ki67. The gene discussed is ACTA1; the disease is cancer.