Having determined that inhibitors of EGFR signaling maintain adult hub cell quiescence and that EGFR pathway activation can cause hub cells to re-enter the cell cycle and transdifferentiate into cyst lineage cells, we asked if EGFR signaling plays a role in testes recovering from CySC ablation, a condition which also stimulated hub cell transdifferentiation (Hétié et al., 2014). Here, EGFR is linked to cyst.