In adult testes, EGFR signaling is required in cyst lineage cells for their encapsulation of germ cells, and this association is vital for germ cell differentiation and maturation into sperm (Hudson et al., 2013; Kiger et al., 2000; Sarkar et al., 2007; Schulz et al., 2002; Tran et al., 2000). Here, EGFR is linked to cyst.