The distribution of the gene set was significantly enriched in the downregulated genes of Rai14+/- group, and indeed, 17 genes out of 18 significant DEGs that are included in the Aston-Major Depressive Disorder DN gene set were downregulated in Rai14+/- mouse brain (Figure 5C and D, Figure 5—figure supplement 1). The gene discussed is RAI14; the disease is major depressive disorder.