MAPK8 and infection: While some studies have identified the JNK mitogen-activated protein kinase (MAPK) or p38 MAPK as inhibiting ROS-induced stress in macrophages infected with mycobacteria (23, 34, 35), we found no differences in the expression or phosphorylation of these MAPKs during Δ51 infection compared to WT and Δ51C (Fig. S3).