At 2000 nM JQ1 for 3 days, IDH status was associated with a statistically significant, yet modest, decrease in cellular proliferation with a 64% and 80% reduction in BrdU + cells compared to controls for IDHwt and IDHmut glioma cells, respectively (Fig. 3B, C; Fig. S2A, B). This evidence concerns the gene IDH1 and central nervous system cancer.