IDH1 and central nervous system cancer: We utilized a panel of IDHwt/mut glioma cell lines, representing Grade 3 and Grade 4 gliomas, along with an IDHwt cell line bearing a stable transgenic R132H IDH1 mutation to investigate the hypothesis that IDHmut gliomas are more sensitive to the antiproliferative and/or cytotoxic effects of BET inhibition.