Based on the fact that Rph3A plays an important role in vesicle transport, we speculate that in the early stages of cerebral ischemia‐reperfusion, the organism mobilizes Rph3A in astrocytes and delivers them to neuronal cells in a specific manner (e.g., in the form of vesicular secretion) for self‐protection through regulatory mechanisms in response to the sudden injury. Here, RPH3A is linked to brain ischemia.