UCP1 and obesity due to melanocortin 4 receptor deficiency: Also, in accordance with the resistance to obesity of mice harboring transgenic overexpression of UCP1 in WAT (Kopecky et al., 1995) and the involvement of UCP1 in diet-induced thermogenesis (von Essen et al., 2017), it is often speculated that NST mediated by UCP1 could serve as a target for obesity treatment.