CD40LG and glomerulonephritis: 6OHDA is known to induce SNS fibers defects in bone marrow, which affects the HSC microenvironment.25,38,42 del Rey et al reported that sympathetic denervation by 6OHDA treatment increased the concentration of IgM and IgG2a in plasma and shortened the survival time in MRL/lpr mice than in control mice.43 Our study demonstrated that 6OHDA treated-MRL/lpr mice exhibited glomerulonephritis and cell infiltration into the tubulointerstitial space, proteinuria, and skin lesions.