For example, the inflammatory transcripts Il6, procaspase-1 and Nlrp3 were specifically upregulated in WAT in WD-fed males (Fig. 3G,J,K), and IL-1β and IL-18 levels were significantly upregulated in the liver of WD-fed males (Fig. 6K,L), but none of these inflammatory pathways were upregulated in females. This evidence concerns the gene IL6 and Wilson disease.