A possible explanation for the best prognosis in IM-M could be that the immune-mediated tumor killing is the strongest in this subtype, as evidenced by the highest ratio of immunostimulatory to immunosuppressive signatures in bulk tumors, as well as the highest enrichment of immunostimulatory signatures (such as activated CD4+ T cells and CD8+ GZMB T cells) and the lowest enrichment of immunosuppressive signatures (such as regulatory CD4+ T cells and resting CD4+ T cells) in single cells in IM-M. Here, CD4 is linked to neoplasm.