Three of these proteins, haptoglobin, hemopexin, and alpha-1-acid glycoprotein 2, were found to have increased abundance in the serum of Rag2−/−Il10−/− mice with chronic inflammation, being identified in an earlier proteomics study of this model by Knutson et al. [50], indicating their utility as biomarkers for global inflammation; these proteins have also been seen to be increased in abundance in response to sepsis [51], chronic obstructive pulmonary disorder [52], and colorectal cancer [53]. Here, ORM2 is linked to colorectal cancer.