PRSS2 and inflammatory bowel disease: The increased abundance in Prss2, a serine protease involved in the remodeling of the extracellular matrix [54], suggests that the inflamed proximal colon tissue can be considered to be in a chronically inflamed state [55] as increased abundance in Prss2 differentiates IBD patients from healthy patients [56], making the five-month exposure of these mice a suitable model for chronic inflammatory bowel disease.