F1 female offspring displayed changes in changes in early-life fear conditioning with no changes to behavior in adulthood.F1 male offspring exhibited altered anxiety-related behaviors and a significant increase in Igf2 mRNA expression in the hippocampus at eight weeks of age.F2 progeny displayed selective behavioral effects. Both male and females spend more time in the open arms of the elevated-plus maze. Only male progeny had increased hippocampus Igf2 mRNA expression. The gene discussed is IGF2; the disease is Anxiety.