CDKN2A and familial pancreatic carcinoma: The association between this syndrome and pancreatic cancer was explicitly observed in patients carrying the p16-Leiden mutation in the CDKN2A gene (deletion of 19 base pairs in exon 2 of the gene CDKN2A; NM_000077.4: c.225_243del19 (p.p75fs)) [75,76].