To explore the mechanism underlying the effect of FAM46A on promotion of ovarian cancer chemo-resistance traits, Signal finder reporter arrays was performed and revealed that the overexpression of FAM46A in both SKOV3 and A2780 cells resulted in TGF-β pathway activation (Figure 5(a)), suggesting that FAM46A might contribute to modulating TGF-β signaling. The gene discussed is TGFB1; the disease is ovarian carcinoma.