Consistently, FAM46A levels were positively correlated with p-Smad2 expression (r = 0.63; P < 0.05) in 10 freshly collected clinical ovarian cancer samples, further suggesting that FAM46A expression was clinically correlated with activities of TGF-β/Smad pathways in ovarian cancer (Figure 6(b)). This evidence concerns the gene SMAD2 and ovarian carcinoma.