In a small pre-test, it was found that Rh(D)-positive patients with ITP without splenectomy tolerated intravenous anti-D well, and this effect was particularly significant in the middle and late pregnancy, where it was effective and safe for both mother and neonate at doses of 50–75 μg/kg (10, 11). Here, RHD is linked to autoimmune thrombocytopenic purpura.