For example, it has been reported that inhibition of the IL-6-JAK/STAT-3 signaling pathway in CRPC cells (C4-2 and CWR22Rv1) sensitizes tumor cells to NK cell-mediated cytotoxic action through changes in the PDL-1 ligand interaction and the expression of NKG2D [56]. The gene discussed is CD274; the disease is neoplasm.