An in vitro study by Lorenzen et al. [31] demonstrated that angiotensin II stimulates AP-1 and promotes the transcriptional processes of miRNA-21, thereby targeting PTEN and Smad7 for degradation and leading to the activation of myocardial fibroblast and progression of myocardial fibrosis. The gene discussed is AGT; the disease is Myocardial fibrosis.