Although an oversimplification, for charting purposes, the cytokines were split into three groups by their generalized tumor-destroying (IFN-γ, IL-2, and IL-5), tumor-promoting (IL-10 and IL-4), or SIRS-associated (IL-1β, IL-6, CXCL-1, and TNF-α) properties [37–62]. This evidence concerns the gene TNF and neoplasm.