To test whether the osteoarthritis degenerative process may be retarded by enhancing production of aggrecan, individual or combinations of growth factors including: FGF2, TGFβ, and members of the BMP family, have been delivered via gene therapy to osteoarthritis models (Trippel et al., 2007; Shi et al., 2013). The gene discussed is FGF2; the disease is osteoarthritis.