CHST11 and mucopolysaccharidosis: Although the expression of TGFß and other TGFß-regulated genes are disrupted in both chondroitin-4-sulfotransferase 1 (C4ST-1 also known as CHST11) (Klüppel et al., 2005) and MPS-VI (Simonaro et al., 2005), detailed aspects of the mechanisms controlling disruptions in skeletogenesis in the mucopolysaccharidoses largely remain to be determined.