TGFB2 and Camurati-Engelmann disease: Targeted deletion of the TGFβ2 gene product alters the overall size and shape of limb rudiments (Sanford et al., 1997), and naturally occurring mutations in the TGFβ2 gene cause Camurati-Engelmann Disease, characterized by thickening of the long bone collar (Campos-Xavier et al., 2001).