HIF1A and pachyonychia congenita: SENP1 might take part in the pathogeneses of PC by activating the HIF1α signaling pathway and its downstream target gene, vascular endothelial growth factor (VEGF) (Bawa-Khalfe et al., 2010; Wang et al., 2019); moreover, SENP1 expression directly correlates with PC aggressiveness and recurrence, and SENP1 silencing in highly metastatic PC cells counteracts the ability to metastasize to the bone (Wang et al., 2013).