SENP1 might take part in the pathogeneses of PC by activating the HIF1α signaling pathway and its downstream target gene, vascular endothelial growth factor (VEGF) (Bawa-Khalfe et al., 2010; Wang et al., 2019); moreover, SENP1 expression directly correlates with PC aggressiveness and recurrence, and SENP1 silencing in highly metastatic PC cells counteracts the ability to metastasize to the bone (Wang et al., 2013). Here, VEGFA is linked to pachyonychia congenita.