MCL1 and osteosarcoma: The same authors demonstrated that MLN4924 alone has only a slight apoptotic effect in osteosarcoma cells while the concomitant inhibition of Mcl-1, an anti-apoptotic protein, considerably enhances the MLN4924 action, suggesting that combining treatments is important to achieve better results in anticancer therapy in osteosarcoma (Zhang et al., 2017).