Another study reported about the resistance to MLN4924, a selective inhibitor of NAE1 and thus of the NEDDylation modification (Soucy et al., 2009), treatment in cancer patients with complete loss of PTEN, indicating that PTEN is necessary for MLN4924 suppression of tumor growth and that PTEN status is useful to discriminate MLN4924-responsive BC patients (Du et al., 2021). Here, NAE1 is linked to cancer.