In addition, the esophageal cancer related gene 2 protein has been shown to increase ubiquitination and degradation of ELAVL1 in the colon cancer-derived RKO cell line and the breast cancer-derived MCF7 cell line, but this protein failed to produce similar effects on several non-ubiquitinable mutant forms of ELAVL1 (Lucchesi et al., 2016). This evidence concerns the gene ELAVL1 and breast carcinoma.