For example, circRHOBTB3 is expressed at relatively low levels in hepatocellular carcinoma, and it has been reported that over-expression of circRHOBTB3 can lead to degradation of ELAVL1 and thus inhibition of the expression of the ELAVL1 target gene PTBP1 (Chen et al., 2021b). This evidence concerns the gene ELAVL1 and hepatocellular carcinoma.