Regarding that, AHR participates in bone remodelling through altering the interplay between bone-forming osteoblasts and bone-resorbing osteoclasts in human osteosarcoma cells (Park et al., 2020); also inhibits osteogenic differentiation in human Osteoblast-Like Cells (Yun et al., 2018); and its inhibition leads to an increase in bone mineral density (BMD) and bone strength in murine models (Yu T.-Y. The gene discussed is AHR; the disease is osteosarcoma.