In CRC, the MCF2LAS1/miR-874-3p/FOXM1 axis (Liao et al., 2018) and MCF2LAS1/miR-874-3p/CCNE1 axis (Huang et al., 2020a) can promote cancer cell apoptosis, inhibit cancer cell proliferation, invasion, migration and EMT process. This evidence concerns the gene CCNE1 and cancer.