HMGB2 and gastric cancer: In GC cell lines the downregulation of the miR-874-3p/HMGB2 axis can upregulate the expression of β-catenin, CCND1, and MYC, which shows that the abnormal activation Wnt/β-catenin signaling pathway may be regulated by the miR-874-3p/HMGB2 axis in GC (Yuan et al., 2020).