Furthermore, studies have showed that knocking-in Cx46 gene in Cx50 gene-deficient mice rescued lens transparency and recovered gap junction coupling and resting voltages with partially improved coupling conductance in differentiating lens fibers, and slightly enhanced postnatal epithelial cell proliferation rates, but microphthalmia remains (White, 2002; White et al., 2007; Wang et al., 2017). Here, GJA8 is linked to microphthalmia.