These include the insulin-regulated human glucose transporter GLUT4 (Camus et al., 2020), a mutant version of the CFTR transporter associated with cystic fibrosis (Gee et al., 2018), and a handful of specifically localized mammalian cargoes in neurons, such as glutamate receptor GluA1, neuroligin, or the potassium channel Kv2.1 (Arnold and Gallo, 2014; Bowen et al., 2017; Stampe Jensen et al., 2017). This evidence concerns the gene KCNA3 and cystic fibrosis.