CD1D and metabolic dysfunction-associated steatotic liver disease: In NAFLD mice, the CD1d KO-HFD group was enriched in the sphingolipid signaling pathway, cortisol synthesis and secretion, Cushing syndrome, sphingolipid metabolism pathways, steroid biosynthesis, ovarian steroidogenesis, and aldosterone synthesis and secretion compared with the WT-HFD group (Figure 5B).