CACNB2 and hypertrophic cardiomyopathy: In 2017, the importance of CACNB2 (gene coding for CaVβ2) as a genetic modifier of a Hypertrophic CardioMyopathy (HCM), in which the causal gene was MYBPC3 (Myosin-Binding Protein C), has been described for the first time (Zhang et al., 2017).