CACNA1A and episodic ataxia type 5: Brugada Syndrome type 4 and Episodic ataxia type 5 present causative mutations in genes coding for CaVβs proteins and other CaV subunits (CACNA2D1 and CACNA1A, and CACNA1A respectively–MalaCard database), corroborating CaVβ involvement in pathological mechanisms in a CaV-linked way (Table 1).