In addition, the high mRNA expression level of SOX1, SOX2, SOX3, SOX5, SOX8, SOX10, SOX14, and SOX18 were positively related with PFS time in HCC patients, while the high mRNA expression level of SOX4, SOX11, and SOX12 predicted poor PFS time in HCC. The gene discussed is SOX3; the disease is hepatocellular carcinoma.