In addition, the high mRNA expression level of SOX1, SOX2, SOX3, SOX5, SOX8, SOX10, SOX14, and SOX18 were positively related with PFS time in HCC patients, while the high mRNA expression level of SOX4, SOX11, and SOX12 predicted poor PFS time in HCC. This evidence concerns the gene SOX18 and hepatocellular carcinoma.