In addition, the top 10 hub genes POSTN, BGN, MMP2, THBS2, CD34, ESR1, VEGFC, AEBP1, CLDN5, and LOXL1 seem to be related with cancer stemness (such as cancer-associated fibroblasts [55], EMT process [56], tumor immune infiltration [57], and metastasis [58]). This evidence concerns the gene ESR1 and cancer.