Sex-determining region Y (Sry)-box-containing (SOX) family members (including SOX1, SOX2, SOX3, SOX4, SOX5, SOX6, SOX7, SOX8, SOX9, SOX10, SOX11, SOX12, SOX13, SOX15, SOX17, and SOX18) are transcription factors with a significant role such as tumor growth and invasion in various of cancers [15–19]. The gene discussed is SOX8; the disease is cancer.