Hypermethylation of the SOX4, SOX8, and SOX10 gene overlapped with the survival curve of hypomethylation HCC patients, but in the early stage of HCC development, hypermethylation of the SOX4, SOX8, and SOX10 genes could indicate a better prognosis (Figure 10). The gene discussed is SOX8; the disease is hepatocellular carcinoma.