TOB1 is the first gastric cancer-related tumor suppressor gene revealed by our research group [18–24], and our group also revealed in the previous study that overexpression of TOB1 in gastric cancer cells can induce autophagy in gastric cancer cells, and its molecular mechanism may be related to downregulation of AKT/mTOR signaling pathway [25]. The gene discussed is AKT1; the disease is gastric cancer.