Therefore, our study further speculated that the overexpression of TOB1 in gastric cancer cells affects the expression of characteristic miRNA molecules represented by miR-218-5p, miR-100-5p, miR-2682-5p, miR-452-5p, miR-125b-1-3p, miR-146a-5p, miR-3615, miR-12136, and miR-548o-3p, which enters gastric cancer cells through the exosomal pathway and exerts biological functions including autophagy. This evidence concerns the gene TOB1 and gastric cancer.