The positive rate of SPOP expression in EC FIGO stage III+IV was higher than that in FIGO stage I+II; muscular layer infiltration > 1/2 was higher than muscular layer infiltration ≤ 1/2; having lymph node metastasis was higher than not having lymph node metastasis (P < 0.05~P < 0.01) (Table 2). The gene discussed is SPOP; the disease is metastatic malignant neoplasm in the lymph nodes.