MIF and rheumatoid arthritis: Today, it is proven that MIF has a key role in both immune and inflammatory responses and it is involved in numerous conditions, such as asthma (Yamaguchi et al., 2000), rheumatoid arthritis (Leech et al., 1999), sepsis (Bozza et al., 2004), atopic dermatitis (Shimizu et al., 1997), atherosclerosis (Burger-Kentischer et al., 2002) and breast cancer (Verjans et al., 2009).