For example, SNPs associated with obesity and type-2 diabetes that are located in noncoding regions of the FTO gene locus interact with the promoter of the IRX3 gene at megabase distances, thus affecting the expression of IRX3, which regulates body weight in mice (Smemo et al., 2014; Claussnitzer et al., 2015). This evidence concerns the gene IRX3 and type 2 diabetes mellitus.